Anti-cancer small molecule JP-8g exhibits potent in vivo anti-inflammatory activity
نویسندگان
چکیده
Spirooxindoles are a class of compounds with diverse biological activity. Previously, we identified a series of spirooxindole-pyranopyrimidine compounds that exhibited broad-spectrum anti-cancer activity. In this study, we evaluated one of these compounds, JP-8g, on mouse models and found that it showed potent in vivo anti-inflammatory activity. Further investigation suggested that JP-8g may execute its anti-inflammatory activity through nitric oxide synthase signaling pathways. Our results suggest that these spirooxindole-pyranopyrimidine class compounds have potential for not only cancer treatment but also inflammation therapy.
منابع مشابه
Spirooxindoles, a potential novel class of anti-inflammatory agents
In a previous study, we described a class of spirooxindole-pyranopyrimidine compounds that had a wide range of anti-cancer activity. In a most recent study, we found that one such compound, JP-8g, were also found to exhibit potent in vivo anti-inflammatory activity. In vitro and in vivo experiments suggested that JP-8g exerts this activity through nitric oxide (NO) signaling pathway. Herein, we...
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